However, as Sherman chases what is left of Buddy, the glowing mass evaporates and thus Sherman cannot restore his intelligence.ĭenise and Cletus arrive too late to save him, and seeing what has happened to Sherman, Denise breaks into tears. The ball is covered with the new formula, which takes Buddy back to an infantile state and eventually to a glowing mass of genetic material for Sherman to suck the genetic material back into his body through a straw, thus putting his DNA back together and returning him to normal. Sherman takes advantage of the canine DNA that crossed with Buddy's, and uses the tennis ball to play fetch. Enlisting the help of Sherman's father Cletus, Denise goes after him. Meanwhile, a worried Denise discovers what has happened and that Sherman's brain damage has progressed to almost eighty percent.
He leaves with Richmond and a tennis ball and head to the competing firm. Richmond confronts him about Buddy's actions, believing the two are working together. In a last-ditch effort to secure the money, Sherman quickly works on a newer, much more potent formula while his mental faculties allow him to. Sherman then decides to end his engagement and break up with Denise. The humiliated Dean fires Sherman, who learns that his brain's deterioration has worsened from Jason.
Buddy also doctors the remainder with fertilizer, which causes chaos at a demonstration the next day when a hamster Sherman uses to demonstrate the youth finding effects instead mutates into an aggressive monster who violates Dean Richmond in front of a live television audience. Buddy, who is trying to sell the formula to a different company, quickly realizes where it is and steals some of it. Realizing he needs to keep the youth formula out of Buddy's hands, Sherman stashes it at his parents' house. To make matters worse, Jason's suspicions prove correct when Sherman discovers that, due to the extraction, his brain cells are beginning to deteriorate. However, he does not dispose of the genetic material and as a result, Buddy becomes a sentient being when a hair from a Basset Hound who was Sherman's test subject finds its way into it and causes such a reaction.
Sherman tries proposing to Denise, but then Buddy kicks in and makes it a perverted sex request, causing Denise to become mortified against him.ĭetermined to be rid of Buddy permanently, and despite Jason warning him of potentially catastrophic consequences for his health, Sherman uses Denise's methodology to isolate and remove the gene in Sherman's DNA where Buddy has manifested and extracts it from inside his body. Despite his good fortune, Sherman has a major problem: the personality of his vanquished alter ego, Buddy Love (Murphy), is still ingrained inside him and causes him to act out in the same crass manner Buddy does. Together, their work has enabled Wellman College to receive a $150 million award from a pharmaceutical firm to the excitement of Dean Richmond (Larry Miller), who has grown to adore and respect Sherman. He has also met and fallen in love with a colleague, Denise Gaines (Janet Jackson), who has developed a method to isolate genetic material and later becomes his fiancée. After finding success with a DNA restructuring formula in the first film, Sherman Klump (Eddie Murphy) has created another formula which enables those who take it to find the Fountain of Youth.